个人简历
董永喜，博士生导师（青年）。
研究方向为：1）天然产物成药性结构修饰；2）基于靶点的小分子药物发现。
近年来，主持国家自然科学基金，贵州省自然科学基金，贵州省中药现代化项目，贵州省卫生厅科学技术基金等各类项目共10项，以第一作者或通讯作者在Bioorganic Chemistry、Biomedicine & Pharmacotherapy、Bioorganic & Medicinal Chemistry Letters、Medicinal Chemistry Research等SCI杂志发表研究论文10余篇。获得专利2项。
联系方式：dongyx01@163.com
一、主持科研项目（代表性）
1．基于GSK-3β/AChE双重抑制的抗AD杂交分子的设计、合成及作用机制研究，国家自然科学基金，2024.01-2027.12。
2.川芎嗪灯盏乙素苷元抗脑卒中孪药的研究，国家自然科学基金，2020.01-2023.12。
3.基于wnt/β-catenin通路的鼠尾草酸抗肿瘤构效关系研究，贵州省自然科学基金，2022.04-2025.03。
二、代表性论著(近三年)
(1)Yongxi Dong*; Fang Wang; Jinlan Wen; Yongqing Mao; hanhui Zhang; Tiemei Long; Zhangxiang Yang; Lei Li; Jiquan Zhang; Li Dong ; Gang Liu*; Jianwei Xu*; Synthesis and bioevaluation of Scutellarein-Tertramethylpyrazine hybrid molecules for the treatment of ischemic stroke,Bioorganic Chemistry, 2024,142,106978.
(2) Li Dong*; Shanhui Zhang; Lina Chen; Jun Lu; Fuhui Zhao; Tiemei Long; Jinlan Wen; Jiayu Huang; Yuanhu Mao; Zhengfang Qi; Jiquan Zhang; Lei Li*;Yongxi Dong*. In vivo anti-hyperuricemia and anti-gouty arthritis effects of the ethanol extract from Amomumvillosum Lour.,Biomedicine & Pharmacotherapy. 2023, 161,114532.
(3)Zheng, Chong; Lv, Shaofang; Ye, Jianfang; Zou, Lu; Zhu, Kai; Li, Haichang;Dong, Yongxi*; Li, Lei*.Metabolomic Insights into the Mechanisms of Ganoderic Acid: Protection against α-Amanitin-Induced Liver Injury.Metabolites, 2023, 13, 1164.
(4)Yongxi Dong*; Jun Lu; Shanhui Zhang; Lina Chen; Jinlan Wen; Fang Wang; Yongqing Mao; Lei Li; Jiquan Zhang; Shanggao Liao*; Li Dong*.Design, synthesis and bioevaluation of 1,2,4- thiadiazolidine-3,5-dione derivatives as potential GSK-3β inhibitors for the treatment of Alzheimer’s disease,Bioorganic Chemistry. 2023, 134,106446.
(5) Yongxi Dong; Mingji Liu; Yongqing Mao; Shuxia Wu; Jinlan Wen; Jun Lu; Lina Chen; Yaxin Yang; Shiyang Ruan; Lei Li; Xinyun Liu; Jiquan Zhang; Shanggao Liao*; Li Dong*.Discovery of 2-(isoxazol-5-yl) phenyl 3,4-dihydroxy- benzoate as a potential inhibitor for the Wnt/β-catenin pathway.Bioorganic Chemistry, 2022, 128,106116.
(6) Shuxia Wu; Jinlan Wen; Mingji Liu; Lina Chen; Yongqing Mao;Lei Li; Shanggao Liao;Yongxi Dong*; Li Dong*.Hybrid molecules of scutellarein and 3, 5, 6-trimethylpyrazine-2-formic acid linked with polar amino acid for ischemic stroke.Medicinal Chemistry Research, 2022, 31,916–924.
(7)Yongxi Dong; Shuxia Wu; Mingji Liu; Jiayu Huang; Yuanhu Mao; Jiquan Zhang; Zhanzhan Yang;Lei Li; Gang Liu*; Shanggao Liao*; Li Dong*; Conjugates of Tetramethylpyrazine’ metabolites and amino acid as potential antiplatelet agents,Medicinal Chemistry Research, 2022, 31,75–84.
三、授权专利
(1)董永喜; 董莉;廖尚高;刘明吉;何迅;杨小生;毛远湖;许建炜 ;一种治疗缺血性脑卒中孪药及其 制备方法, 2021-7-9,中国, ZL 201910538346.x (专利)
(2)董永喜;董莉;刘明吉;吴淑霞;毛永清;廖尚高;何迅;张吉泉;周孟;关焕玉;徐国波;杨小生;一种2-(异噁唑-5-基)苯基-3,4-二羟基苯甲酸酯及其衍生物及合成方法和应用, 2023-10-20,中国, ZL 202210520035.2
