廖尚高教授简介

廖尚高教授，博士，博士研究生导师，博士后合作导师，现为贵州医科大学药学院副院长，贵州省高等学校道地药材慢性病防治工程研究中心主任，“贵州省中药、民族药活性物质发现新技术开发应用创新人才团队”领衔人。贵州省百层次创新型人才（2020）、省管专家（2019），贵州省优秀青年科技人才培养对象（2015）、“西部之光”访问学者（2012）、国家药品食品管理局化妆品评审专家（2010-）、贵州省优秀教师（2014）。1995.06毕业于北京师范大学化学系，获理学学士学位；2007.06年毕业于中国科学院上海药物研究所药物化学专业（导师：岳建民院士），获理学博士学位；2011.09-2012.08，在天津中医药大学开展“西部之光”访问学习（导师：张伯礼院士）；2015.08-2016.09在美国加州大学戴维斯分校代谢组学知名专家Oliver Fiehn教授的实验室访问学习。Asian Toxicology Research编委，Frontiers in Pharmacology中Gastrointestinal and Hepatic Pharmacology的Review Editor，European Journal of Medicinal Chemistry、Journal of Ethnopharmacology、Analytica Chimica Acta等30余个国际SCI期刊审稿专家。目前已发表论文200余篇，其中SCI期刊论文100余篇H-index为28。在JCR一区期刊发表论文20余篇；申请专利60余项，已获得专利授权29项。在化学类顶级期刊Chemical Reviews，Springer国际出版机构上以第一作者身份撰写权威评论各一篇。

科研项目：主持有国家自然科学基金4项、贵州省百层次创新型人才项目、贵州省优秀青年科技人才专项资金、贵州省人民政府省长基金等项目的研究。

获奖：获上海市浦东新区第五届优秀科技论文一等奖、贵州省科技成果转化一等奖、贵州省科技进步一等奖以及贵州省自然科学一等奖和二等奖各一项。

主要研究方向：天然药物化学、中草药药效物质基础、活性物质筛选新方法、中草药药效评价与作用机制研究、活性天然产物结构修饰与新药研发、基于药食两用中草药的健康产品研发、中药化妆品研发等。

第一或通讯作者部分代表性论文：

[1] Fu-Rui Wang; Mei-Lin Peng; Qin-Feng Zhu; Ling-Ling Yu; Li-Jie Zhang; Shi-Ying Xu; Qian Wang; Jing Li; Xun He; Shang-Gao Liao, Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.Journal of Ethnopharmacology 2024, 117830.

[2] Huanyu Guan; Qian Wang; Yao Mei; Junyan Ran; Fanli Zeng; Haimin Cai; Daoping Wang; Shenggang Yang; Min Zhang; Yue Shi; Shanggao Liao; Pengfei Li, A multistep approach for exploring quality markers of Shengjiang Xiexin decoction by integrating plasma pharmacochemistry-pharmacokinetics-pharmacology.Journal of Pharmaceutical and Biomedical Analysis 2024, 241, 115999

[3] Xiao-Li Guo; Yan-Yan Gao; Ya-Xin Yang; Qin-Feng Zhu; Huan Yu Guan; Xun He; Chun-Lei Zhang; Ya Wang; Guo-Bo Xu; Shu-Han Zou; Mao-Chen Wei; Jian Zhang; Jin-Juan Zhang; Shang-Gao Liao, Amelioration effects of α-viniferin on hyperuricemia and hyperuricemia-induced kidney injury in mice.Phytomedicine 2023, 116, 154868.

[4] Yongxi Dong; Jun Lu; Shanhui Zhang; Lina Chen; Jinlan Wen; Fang Wang; Yongqing Mao; Lei Li; Jiquan Zhang; Shanggao Liao; Li Dong, Design, synthesis and bioevaluation of 1,2,4-thiadiazolidine-3,5-dione derivatives as potential GSK-3β inhibitors for the treatment of Alzheimer's disease.Bioorganic Chemistry 2023, 134, 106446.

[5]Xue-Long Yan; Bei-Ling Chen; Fang-Yu Yuan; Qin-Feng Zhu; Xu Zhang; Yan Lin; Qing-De Long; Shang-Gao Liao. Six new tigliane diterpenoids with anti-inflammatory activity fromEuphorbia kansuensis.Arabian Journal of Chemistry 2022: 103807.

[6]Huanyu Guan; Pengfei Li; Qian Wang; Fanli Zeng; Daoping Wang; Mei Zhou; Meng Zhou; Xun He; Shanggao Liao; Weidong Pan. Systematically exploring the chemical ingredients and absorbed constituents ofPolygonum capitatum in hyperuricemia rat plasma using UHPLC-Q-Orbitrap HRMS.Molecules 2022, 27(11): 3521.

[7]Yongxi Dong; Shuxia Wu; Mingji Liu; Jiayu Huang; Yuanhu Mao; Jiquan Zhang; Zhanzhan Yang; Lei Li; Gang Liu; Shanggao Liao. Conjugates of tetramethylpyrazine’metabolites and amino acid as potential antiplatelet agents.Medicinal Chemistry Research 2022, 31(1): 71-84.

[8]Hong Zhang; Rong-Hong Zhang; Xiang-Ming Liao; Dan Yang; Yu-Chan Wang; Yong-Long Zhao; Guo-Bo Xu; Chun-Hua Liu; Yong-Jun Li; Shang-Gao Liao; Meng Zhou. Discovery of β-carboline derivatives as a highly potent cardioprotectant against myocardial ischemia-reperfusion injury.Journal of Medicinal Chemistry 2021, 64(13): 9166-9181.

[9]Chun-Lei Zhang; Jin-Juan Zhang; Qin-Feng Zhu; Huan-Yu Guan; Ya-Xin Yang; Xun He; Yao Fu; Teng-Xiang Chen; Li Dong; Xiao-Sheng Yang; Kai-Fa Tang; Guo-Bo Xu; Shang-Gao Liao. Antihyperuricemia and antigouty arthritis effects of Persicaria capitata herba in mice.Phytomedicine 2021, 93: 153765.

[10]Xue-Long Yan; Sang Jun; Xu Zhang; Yan Lin; Qing-De Long; Qin-Feng Zhu; Shang-Gao Liao. Euphorboside A, a cytotoxic meroterpenoid glycoside with an unusual humulene-phloroglucinol skeleton fromEuphorbia kansuensis.Fitoterapia 2021, 153: 104966.

[11]Guo-Bo Xu; Qin-Feng Zhu; Zhen Wang; Chun-Li Zhang; Xin Yang; Jin-Juan Zhang; Fu-Rui Wang; Jun Liu; Meng Zhou; Yong-Lin Wang; Xun He; Li-She Gan; Shang-Gao Liao. Pseudosterins A–C, Three 1-Ethyl-3-formyl-β-carbolines fromPseudostellaria heterophylla and Their Cardioprotective Effects.Molecules 2021, 26(16): 5045.

[12]Guo-Bo Xu; Fei-Yu Yang; Xin-Yu Wu; Rui Li; Meng Zhou; Bing Wang; Xiao-Sheng Yang; Ting-Ting Zhang; Shang-Gao Liao. Two new dihydroisocoumarins with antimicrobial activities from the fungusPenicillium sp. XR046 collected from Xinren coal area.Natural Product Research 2021, 35(9): 1445-1451.

[13]Shan Wang; Rong-Hong Zhang; Hong Zhang; Yu-Chan Wang; Dan Yang; Yong-Long Zhao; Guo-Yi Yan; Guo-Bo Xu; Huan-Yu Guan; Yan-Hua Zhou; Dong-Bing Cui; Ting Liu; Yong-Jun Li; Shang-Gao Liao; Meng Zhou. Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities.European Journal of Medicinal Chemistry 2021, 222: 113573.

[14]Guang-Gui Chen; Qin-Feng Zhu; Xing-Mei Long; Qian Lu; Kai-Yu Li; Qian Chen; Meng Zhou; Shang-Gao Liao; Guo-Bo Xu. Antibacterial activities of the chemical constituents ofSchizophyllum commune MST7-3 collected from coal area.Natural Product Research 2021: 1-10.

[15]Li Dong; Xing-Xing Liu; Shu-Xia Wu; Yao Mei; Ming-Ji Liu; Yong-Xi Dong; Jia-Yu Huang; Yong-Jun Li; Yong Huang; Yong-Lin Wang; Shang-Gao Liao. Rhizoma Bletillae polysaccharide elicits hemostatic effects in platelet-rich plasma by activating adenosine diphosphate receptor signaling pathway.Biomedicine & Pharmacotherapy 2020, 130: 110537.

[16]Liang-Cai Lin; Huan-Yu Guan; Rui Li; Xiang-Ming Liao; Fei-Fei Zhao; Min Wang; Jing Li; Guo-Bo Xu; Xun He; Jin-Juan Zhang; Yong-Jun Li; Yong-Lin Wang; Meng Zhou; Shang-Gao Liao. Auriculatone sulfate effectively protects mice against acetaminophen-induced liver injury.Molecules 2019, 24(20): 3642.

[17]Meng Zhou; Rui Li; Xiang-Ming Liao; Zheng Wang; Guo-Bo Xu; Zi-Peng Gong; Yuan Lu; Xun He; Yong-Jun Li; Yong-Lin Wang; Lin Zheng; Shang-Gao Liao. Screening and analysis of potentially active components in Shenxiong glucose injection using UHPLC coupled with photodiode array detection and MS/MS.Journal of Separation Science 2018, 41(10): 2130-2138.

[18]Guo-Bo Xu; Yao-Hua Xiao; Qing-Yan Zhang; Meng Zhou; Shang-Gao Liao. Hepatoprotective natural triterpenoids.European Journal of Medicinal Chemistry 2018, 145: 691-716.

[19]Xiang-Ming Liao; Xun He; Guo-Bo Xu; Zhen Wang; Jing Li; Huan-Yu Guan; Meng Zhou; Yong-Jun Li; Yong-Lin Wang; Li-She Gan; Shang-Gao Liao. Two nitrogen-containing compounds fromPseudostellaria heterophylla.Natural Product Communications 2018, 13(3): 343-346.

[20]Meng Zhou; Rong-Hong Zhang; Min Wang; Guo-Bo Xu; Shang-Gao Liao. Prodrugs of triterpenoids and their derivatives.European Journal of Medicinal Chemistry 2017, 131: 222-236.

[21]Meng Zhou; Min Wang; Rui-Feng Zhong; Xiang-Ming Liao; Lian-Li Deng; Guo-Bo Xu; Xun He; Jing Li; Yong-Jun Li; Ting Liu; Yong-Lin Wang; Shang-Gao Liao. Discovery and structure-activity relationship of auriculatone: A potent hepatoprotective agent against acetaminophen-induced liver injury.Bioorganic and Medicinal Chemistry Letters 2017, 27(16): 3636-3642.

[22]Min Wang; Guo-Bo Xu; Jun Liu; Yue-Hao Zhang; Jun-Hong Liu; Jing Li; Meng Zhou; Yao-Hua Xiao; Xun He; Shang-Gao Liao. Buxusoside, a flavonoid disaccharide fromBuxus sinica.Natural Product Communications 2017, 12(14): 525-526.

[23]Shang-Gao Liao; Jian-Min Yue. Dimeric Sesquiterpenoids.Progress in the Chemistry of Organic Natural Products2016, 101: 1-112.

[24]Huan-Yu Guan; Yan Yan; Yong-Lin Wang; Ai-Min Wang; Jun-Hong Liu; Xun He; Yong-Jun Li; Yong Huang; Shang-Gao Liao. Isolation and characterization of two new 2-isobutylmalates fromBletilla striata.Chinese Journal of Natural Medicines 2016, 14(11): 871-875.

[25]Rui-Feng Zhong; Guo-Bo Xu; Zheng Wang; Ai-Min Wang; Huan-Yu Guan; Jing Li; Xun He; Jun-Hong Liu; Meng Zhou; Yong-Jun Li; Yong-Lin Wang; Shang-Gao Liao. Identification of anti-inflammatory constituents fromKalimeris indicawith UHPLC-ESI-Q-TOF-MS/MS and GC-MS.Journal of Ethnopharmacology 2015, 165: 39-45.

[26]Ya-Xin Yang; Ai-Min Wang; Zheng Wang; Yong-Lin Wang; Jin Zhang; Jun-Hong Liu; Xun He; Yong-Jun Li; Xiao-Yan Hao; Shang-Gao Liao. Chemical fingerprinting and multi-marker determination of the roots ofIndigofera stachyoides by UHPLC-Q-TOF/MS.Current Pharmaceutical Analysis 2015, 11(4): 260-268.

[27]Shang-Gao Liao; Zhen Wang; Ya-Yun Wu; Li-Juan Zhang; Jing Li; Ai-Min Wang; Yong-Jun Li; Yan-Yu Lan; Yong-Lin Wang. Structures and hepatocytotoxicity of co-occurring substances in oleanolic acid tablets.Pakistan Journal of Pharmaceutical Sciences 2014, 27(3): 601-605.

[28]Shang-Gao Liao; Zhen Wang; Fa Sun; Li-Juan Zhang; Xun He; Lin Zheng; Ai-Min Wang; Yong-Jun Li; Yong Huang; Yan-Yu Lan; Yong-Lin Wang. Differentiation of isomeric polyphenolic glycosides that possess regioisomeric acylated monosaccharide residues by electrospray ionization-tandem mass spectrometry.Spectroscopy Letters 2014, 47(1): 19-23.

[29]Kai-Long Ji; Ping Zhang; Hua-Bin Hu; Shuai Hua; Shang-Gao Liao; You-Kai Xu. Limonoids from the leaves and twigs ofWalsura yunnanensis.Journal of Natural Products 2014, 77(8): 1764-1769.

[30]Zhen Wang; Shang-Gao Liao; Yan He; Jing Li; Rui-Feng Zhong; Xun He; Ying Liu; Ting-Ting Xiao; Yan-Yu Lan; Qing-De Long; Yong-Lin Wang. Protective effects of fractions fromPseudostellaria heterophylla against cobalt chloride-induced hypoxic injury in H9c2 cell.Journal of Ethnopharmacology 2013, 147(2): 540-545.

[31]Shang-Gao Liao; Li-Juan Zhang; Fa Sun; Zhen Wang; Xun He; Ai-Min Wang; Yong-Jun Li; Yong Huang; Yan-Yu Lan; Bo-Li Zhang; Yong-Lin Wang. Identification and characterisation of phenolics inPolygonum capitatum by ultrahigh-performance liquid chromatography with photodiode array detection and tandem mass spectrometry.Phytochemical Analysis 2013, 24(6): 556-568.

[32]Shang-Gao Liao; Yue-Ting Li; Li-Juan Zhang; Zhen Wang; Teng-Xiang Chen; Yong Huang; Jing Li; Ai-Min Wang; Yong-Jun Li; Yan-Yu Lan; Yong-Lin Wang. UPLC-PDA-ESI-MS/MS analysis of compounds extracted by Cardiac h9c2 cell fromPolygonum orientale.Phytochemical Analysis 2013, 24(1): 25-35.

[33]Bing Liu; Lin Yang; You-Kai Xu; Shang-Gao Liao; Huai-Rong Luo; Zhi Na. Two new triterpenoids fromGelsemium elegans andAglaia odorata.Natural Product Communications 2013, 8(10): 1373-1376.

[34]You-Kai Xu; Shang-Gao Liao; Zhi Na; Hua-Bin Hu; Yan Li; Huai-Rong Luo. Gelsemium alkaloids, immunosuppressive agents fromGelsemium elegans.Fitoterapia 2012, 83(6): 1120-1124.

[35]Ting Tang; Shang-Gao Liao; Zhi Na; Yan Li; You-Kai Xu. Dysoxylentin A, the first 21-nortriterpenoid bearing a 2-(propan-2-ylidenyl)furan-3(2H)-one, fromDysoxylum lenticellatum.Tetrahedron Letters 2012, 53(9): 1183-1185.

[36]Shang-Gao Liao; Li-Juan Zhang; Zhen Wang; Fa Sun; Yong-Jun Li; Ai-Min Wang; Yong Huang; Yan-Yu Lan; Yong-Lin Wang. Electrospray ionization and collision-induced dissociation tandem mass spectrometric discrimination of polyphenolic glycosides: exact acylation site determination of the O-acylated monosaccharide residues.Rapid Communications in Mass Spectrometry 2012, 26(21): 2483-2492.

[37]Shang-Gao Liao; Zhen Wang; Jing Li; Ying Liu; Yue-Ting Li; Li-Juan Zhang; Qing-De Long; Yong-Lin Wang. Cytotoxic sesquiterpene lactones fromVernonia bockiana.Chinese Journal of Natural Medicines 2012, 10(3): 230-233.

[38]Shang-Gao Liao; Li-Juan Zhang; Fa Sun; Jin-Juan Zhang; A. Ying Chen; Yan-Yu Lan; Yong-Jun Li; Ai-Min Wang; Xun He; Ying Xiong; Li Dong; Xiao-Jun Chen; Yue-Ting Li; Li Zuo; Yong-Lin Wang. Antibacterial and anti-inflammatory effects of extracts and fractions fromPolygonum capitatum.Journal of Ethnopharmacology 2011, 134(3): 1006-1009.

[39]Shang-Gao Liao; Li-Juan Zhang; Cui-Bing Li; Yan-Yu Lan; Ai-Min Wang; Yong Huang; Lin Zhen; Xiao-Zhong Fu; Wen Zhou; Xiao-Lan Qi; Zhi-Zhong Guan; Yong-Lin Wang. Rapid screening and identification of caffeic acid and its esters inErigeron breviscapus by ultra-performance liquid chromatography/tandem mass spectrometry.Rapid Communications in Mass Spectrometry 2010, 24(17): 2533-2541.

[40]Shang-Gao Liao; Tao Yuan; Chen Zhang; Sheng-Ping Yang; Yan Wu; Jian-Min Yue. Cinnacassides A-E, five geranylphenylacetate glycosides fromCinnamomum cassia.Tetrahedron 2009, 65(4): 883-887.

[41]Shang-Gao Liao; Hua-Dong Chen; Jian-Min Yue. Plant orthoesters.Chemical Reviews 2009, 109(3): 1092-1140.

[42]Shang-Gao Liao; Yan Wu; Jian-Min Yue. Lignans fromWikstroemia hainanensis.Helvetica Chimica Acta 2006, 89(1): 73-80.

[43]Shang-Gao Liao; Bang-Le Zhang; Yan Wu; Jian-Min Yue. New phenolic components fromDaphne giraldii. Helvetica Chimica Acta 2005, 88(11): 2873-2878.

[44]Shang-Gao Liao; Zha-Jun Zhan; Sheng-Ping Yang; Jian-Min Yue. Lathyranoic acid A: First secolathyrane diterpenoid in nature fromEuphorbia lathyris.Organic Letters 2005, 7(7): 1379-1382.