徐国波，男，教授，博士/硕士研究生导师。贵州医科大学药学院天然药物化学教研室副主任。2014年毕业于四川大学，获理学博学位。2018.8-2019.8赴美国亚利桑那大学访学。曾获西部中国科学院“朱李月华优秀博士生奖”、贵州省自然科学二等奖、优秀硕士/本科论文指导教师奖，全国大学生化学实验创新设计大赛一等奖指导教师。研究方向为活性天然小分子的发现、结构修饰及其作用机制。主持国家自然基金项目4项，贵州省科技厅基础研究计划、贵州省教育厅自然科学青年项目各1项，以及贵州医科大学人才引进项目1项。目前已在Organic Letters, European Journal of Medicinal Chemistry,Frontiers in Microbiology, Journal of Natural Products, Rapid Communications in Mass Spectrometry, Journal of Ethnopharmacology, Natural Products Research, Archives of Pharmacal Research, Molecules，《中药材》、《天然产物研究与开发》等期刊发表论文70余篇。申请专利7项。承担本科《中药化学》、《天然药物化学》、《药物分离纯化技术》、《波谱解析》以及研究生《高等天然药物化学》等课程。参编国家规划教材科学出版社和中医药出版社《天然药物化学》各一部。
联系邮箱：xguobo@163.com
代表性论文：
1.Fu-Rui Wang, Mei-Lin Peng, Qin-Feng Zhu, Ling-Ling Yu, Li-Jie Zhang, Shi-Ying Xu, Qian Wang, Jing Li, Xun He, Shang-Gao Liao***, Jun-Li Ao**, Guo-Bo Xu*.Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.Journal of Ethnopharmacology, 2024,325:117830.
2.Peng-Wei Wei, Xu Wang, Cong Wang, Ming Chen, Meng-Zhu Liu, Wen-Xia Liu, Yan-Ling He, Guo-Bo Xu**, Xiao-He Zheng, Hua Zhang***, Hong-Mei Liu****, Bing Wang*.Ginkgo biloba L. exocarp petroleum ether extract inhibits methicillin-resistantStaphylococcus aureus by modulating ion transport, virulence, and biofilm formation in vitro and in vivo.Journal of Ethnopharmacology, 2024,328:117957.
3.Xue-Qing Qian (#1), Guo-Bo Xu (#1), Ling-Yan Liu, Tao Yang, Guo-Lin Zhang, Guo-You Li. Chaetonigrisins A-L, a group of 3-indole-1,2-propanediol derived alkaloids fromChaetomium nigricolorYT-2.Bioorganic Chemistry, 2023, 130, 106201.
4. Bin Wang* (#), Chao-Rong Song (#), Qin-Yan Zhang, Peng-Wei Wei, Xu Wang, Yao-Hang Long, Yong-Xin Yang, Shang-Gao Liao, Hong-Mei Liu *, Guo-Bo Xu *. Thefusaric acid derivative qy17 inhibitsStaphylococcus haemolyticus by disrupting biofilm formation and the stress response via altered gene expression.Frontiers in Microbiology. 2022, 13: 822148.
5. Guo-Bo Xu, Ya-Ming Xu, E. M. Kithsiri Wijeratne, Fatemeh Ranjbar, Manping X. Liu, A. A. Leslie Gunatilaka. Cytotoxic physalins from aeroponically grownPhysalis acutifolia.Journal of Natural Products, 2021, 84, 187−194.
6. Chun-Lei Zhang, Jin-Juan Zhang, Qin-Feng Zhu, Huan-Yu Guan, Ya-Xin Yang, Xun He, Yao Fu, Teng-Xiang Chen, Li Dong, Xiao-Sheng Yang, Kai-Fa Tang, Guo-Bo Xu*, Shang-Gao Liao*. Antihyperuricemia and antigouty arthritis effects ofPersicaria capitata herba in mice.Phytomedicine, 2021, 93: 153765.
7.Guo-Bo Xu, Yao-Hua Xiao, Qing-Yan Zhang, Shang-Gao Liao*. Hepatoprotective natural triterpenoids.European Journal of Medicinal Chemistry, 2018, 145: 691-716.
8.Rui-Feng Zhong (#1), Guo-Bo Xu (#1), Zheng Wang, Ai-MinWang, Huan-Yu Guan, Jing Lia, Xun He, Jun-Hong Liu, Meng Zhou, Yong-Jun Li, Yong-Lin Wang, Shang-Gao Liao*. Identification of anti-inflammatory constituents from Kalimeris indica with UHPLC-ESI-Q-TOF-MS/MS and GC–MS.Journal ofEthnopharmacology, 2015, 165: 39-45.
9. Guo-Bo Xu, Gu He, Huan-Huan Bai, Tao Yang, Guo-Lin Zhang, Lin-Wei Wu, Guo-You Li. Indole Alkaloids fromChaetomium globosum.Journal of Natural Products, 2015, 78, 1479-1485.
10.Guo-Bo Xu, Tao Yang, Jin-Ku Bao, Dong-Mei Fang, Guo-You Li. Isochaetomium A2, Anewbis (naphthodihydropyran-4-one) withantimicrobial andimmunologicalactivities fromfungusChaetomium microcephalum.Archives of Pharmacal Research, 2014, 37(5):575-579.
11. Guo-Bo Xu, Li-Mei Li, Tao Yang, Guo-Lin Zhang, Guo-You Li. Chaetoconvosins A and B, Alkaloids withnewskeleton fromfungusChaetomium convolutum.Organic Letters, 2012, 14 (23): 6052-6055.
12. Guo-Bo Xu, Li-Mei Li, Dong-Mei Fang, Guo-You Li, Guo-Lin Zhang, Zhi-Jun Wu. Electrosprayionizationtandemmassspectrometry ofchaetoglobosins.Rapid Communications in Mass Spectrometry, 2012, 26(18): 2115-2122.
