个人简介
关焕玉，副教授，博士，硕士生导师，青年博士生导师
学科：药物分析
邮箱：guanhuanyu630@163.com
研究方向：中药药效物质筛选及体内代谢处置研究
教育和工作经历
2019-06至2022-06,贵州省中科院天然产物化学重点实验室，博士后
2014-07至2018-07,北京协和医学院药用植物研究所,生药学, 博士
2008-07至2011-07,贵州医科大学,药剂学, 硕士
2004-09至2008-07,天津医科大学,药物制剂, 学士
主持和参与的项目：
分别主持国家自然科学基金青年基金、国家自然科学基金地区基金，贵州省科学技术厅、贵州省卫生健康委和贵州省中医药管理局科学技术研究项目数项，同时参与多个纵向课题和横向课题。
学术活动：
任中华中医药学会青年委员，担任Journal of Ethnopharmacology、Journal of Separation Science和Frontiers in Pharmacology等多个SCI期刊审稿人。
主要代表性论著：
l Huanyu Guan; Qian Wang; Yao Mei; Junyan Ran; Fanli Zeng; Haimin Cai; Daoping Wang; Shenggang Yang; Min Zhang; Yue Shi; Shanggao Liao; Pengfei Li; A multistep approach for exploring quality markers of Shengjiang Xiexin decoction by integrating plasma pharmacochemistry-pharmacokinetics-pharmacology, Journal of Pharmaceutical and Biomedical Analysis, 2024(241),115999.
l Huanyu Guan; Pengfei Li; Qian Wang; Fanli Zeng; Jiashuo Wu; Fangqing Zhang; Shanggao Liao; Yue Shi; Deciphering the chemical constituents of Shengjiang Xiexin decoction by ultrahigh‐performance liquid chromatography‐quadrupole/orbitrap high‐resolution mass spectrometry and the impact of 20 characteristic components on multidrug resistance‐associated protein 2 in the vesicular transport assay, Journal of Separation Science, 2022, 45: 3459-3479.
l Huanyu Guan; Pengfei Li; Qian Wang; Fanli Zeng; Daoping Wang; Mei Zhou; Meng Zhou; Xun He; Shanggao Liao; Weidong Pan; Systematically Exploring the Chemical Ingredients and Absorbed Constituents of Polygonum capitatum in Hyperuricemia Rat Plasma Using UHPLC-Q-Orbitrap HRMS, Molecules, 2022, 27(11): 3521-3521.
l Chunlei Zhang; Jinjuan Zhang; Qinfeng Zhu;Huanyu Guan; Yaxin Yang; Xun He; Yao Fu; Tengxiang Chen; Li Dong; Xiaosheng Yang; Kaifa Tang; Guobo Xu; Shanggao Liao ; Antihyperuricemia and antigouty arthritis effects of Persicaria capitata herba in mice,Phytomedicine, 2021, 93: 153765.
l Huanyu Guan, Xiaomei Luo, Xiaoyan Chang, Meifeng Su, Zhuangzhuang Li, pengfei Li, Xiaoming Wang, Yue Shi*, Identification of the Chemical Constituents of an Anti-Arthritic Chinese Medicine Wen Luo Yin by Liquid Chromatography Coupled with Mass Spectrometry, Molecules, 2019, 24(2), 233.
l Huanyu Guan; Xiaoming Wang; Shiping Wang; Yang He; Jiajing Yue; Shanggao Liao; Yuanda Huang; Yue Shi; Comparative intestinal bacteria-associated pharmacokinetics of 16 components of Shengjiang Xiexin decoction between normal rats and rats with irinotecan hydrochloride (CPT-11)- induced gastrointestinal toxicity in vitro using salting-out sample preparation and LC-MS/MS, RSC Advances, 2017, 7(69): 43621-43635
l Huanyu Guan; Pengfei Li; Xiaoming Wang; Jiajing Yue; Yang He; Xiaomei Luo; Meifeng Su; Shanggao Liao; Yue Shi; Shengjiang Xiexin Decoction Alters Pharmacokinetics of Irinotecan by Regulating Metabolic Enzymes and Transporters: A Multi-Target Therapy for Alleviating the Gastrointestinal Toxicity, Frontiers in Pharmacology, 2017, 8: 769
l Huanyu Guan, Kaitong Li, Xiaoming Wang, Xiaomei Luo, Meifeng Su, Wenting Tan, Xiaoyan Chang, Yue Shi*, Identification of Metabolites of the Cardioprotective Alkaloid Dehydrocorydaline in Rat Plasma and Bile by Liquid Chromatography Coupled with Triple Quadrupole Linear Ion Trap Mass Spectrometry. Molecules 2017, 22(10), 1686.
授权专利及学术奖励
l 关焕玉;廖尚高;张春雷;李芮;马良会;何迅;廖兴江;徐国波;周孟;董永喜;王磊;董莉; 杨小生;头花蓼在调节尿酸方面的应用, 2021-09-10,中国, ZL201910590864.6 (专利)
l 中草药物质基础的发现及其应用研究,贵州省人民政府,自然科学, 省部二等奖, 2022(廖尚高;徐国波;何迅;周孟;关焕玉;李勇军; 王永林) (科研奖励)
